Cytarabine treatment of human T-lymphoid cells induces decreased HIV-1 receptor expression and reduced HIV-1 susceptibility |
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Authors: | Gröschel B Kaufmann A Cinatl J Doerr H W Cinatl J |
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Institution: | Institute of Medical Virology, Johann Wolfgang Goethe University Frankfurt/M, Germany. |
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Abstract: | Continuous cultivation of T-lymphoid C8166 cells in the presence of pharmacological relevant concentration of cytarabine (Ara-C) results in significantly decreased expression of CD4 and CXCR4 molecules, the major cellular receptor and co-receptor of T-lymphotropic HIV-1 isolates. This change in receptor expression leads to decreased susceptibility of Ara-C resistant cells to HIV-1 infection demonstrated by reduced binding and penetration of HI-virus. |
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