Synthesis and antiproliferative activity of some 4'-C-hydroxymethyl-alpha- and -beta-D-arabino-pentofuranosyl pyrimidine nucleosides |
| |
Authors: | Griffon J F Montgomery J A Secrist J A |
| |
Affiliation: | Southern Research Institute, P.O. Box 55305, Birmingham, Alabama 35255-5305, USA. |
| |
Abstract: | A suitably protected 4-C-hydroxymethyl-arabino-pentofuranose was prepared and condensed with the following nucleobases: uracil, 5-fluorouracil and thymine. The corresponding cytosine and 5-fluorocytosine derivatives have also been obtained respectively from the uracil and 5-fluorouracil nucleosides. Separation of the anomeric mixtures followed by deprotection afforded the target compounds that were found to be non-cytotoxic to CCRF-CEM leukemia cells. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|