1,2-disubstituted cyclohexane carbocyclic analogues of nucleosides |
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Authors: | Viña D Santana L Uriarte E |
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Affiliation: | Facultad de Farmacia, Universidad de Santiago de Compostela, Spain. |
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Abstract: | Several compounds of a new series of cyclohexane-based 1,2-disubstituted carbonucleoside analogues, were synthesized. The adenine and uridine derivatives, were prepared by construction of the heterocyclic base on the primary amino group of 2-aminocyclohexylmethanol, and the thymine derivative by condensation of 2-hydroxycyclohexylmethanol with thymine using the Mitsunobu reaction. |
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