Large-scale manufacturing of all four 2'-deoxynucleosides via novel strategies including a chemo-enzymatic process |
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| Authors: | Komatsu H Awano H Tanikawa H Itou K Ikeda I |
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| Institution: | Chemical Synthesis Laboratory, Mitsui Chemicals Inc., 1144 Togo, Mobara-shi, Chiba 297-0017, Japan. |
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| Abstract: | A chemical synthesis of 2-deoxyribose-1-phosphate 2 and its enzymatic conversion into purine 2'-deoxynucleosides (dNus) are shown. Besides the chemo-enzymatic process for purine dNus, a modified process for practical dC preparation is also established. Consequently, a series of practical manufacturing processes of all four dNus have been realized via novel strategies. |
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