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Synthesis of 2',3'-dideoxy-2',3'-didehydro nucleosides via a serendipitous route |
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| Authors: | Guo Z Sanghvi Y S Brammer L E Hudlicky T |
| Affiliation: | Isis Pharmaceuticals, Inc., 2292 Faraday Avenue, Carlsbad, California 92008, USA. |
| Abstract: | This paper describes a "green" synthesis of 2',3'-unsaturated 2',3'-dideoxynucleosides via an electrochemical reaction. Using this approach d4T, d4U, ddA and ddI can be synthesized in high yields. |
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