Unnatural enantiomers of 5-azacytidine analogues: syntheses and enzymatic properties |
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Authors: | Gaubert G Gosselin G Eriksson S Vita A Maury G |
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Affiliation: | UMR 5625 du CNRS, Département de Chimie, Université Montpellier II, Place Bataillon, 34095 Montpellier, France. |
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Abstract: | 2'-Deoxy-beta-L-5-azacytidine(L-Decitabine), beta-L-5-azacytidine, and derivatives were stereospecifically prepared starting from L-ribose or L-xylose. D- and L-enantiomers of 2'-deoxy-beta-5-azacytidine were weak substrates of human recombinant deoxycytidine kinase (dCK), whereas both enantiomers of beta-5-azacytidine or the L-xylo-analogues were not substrates of the enzyme. None of the reported derivatives of beta-L-5-azacytidine was a substrate of human recombinant cytidine deaminase (CDA). |
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