Synthesis and antiviral activity of D- and L-2'-azido-2',3'-dideoxy-4'-thiopyrimidine and purine nucleosides |
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| Authors: | Jeong L S Kim Y H Kim H O Yoo S J Park Y H Yeon S H Chun M W Kim H D |
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| Institution: | College of Pharmacy, Ewha Womans University, Seoul, Korea. |
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| Abstract: | Novel D- and L-2'-azido-2',3'-dideoxy-4'-thionucleosides were synthesized starting from L- and D-xylose via D- and L-4-thioarabitol derivative as key intermediates and evaluated for antiviral activity, respectively. When the final nucleosides were tested against HIV-1, HSV-1, HSV-2, and HCMV, they were found to be only active against HCMV without cytotoxicity up to 100 micrograms/ml. |
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