Structure-activity relationships of apio nucleosides as potential antiviral agents |
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| Authors: | Jeong L S Moon H R Hong J H Yoo S J Choi W J Kim H O Ahn H S Baek H W Chun M W Kim H D Kim J Choi J R |
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| Affiliation: | College of Pharmacy, Ewha Womans University, Seoul, Korea. |
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| Abstract: | Several types of novel apio nucleosides were synthesized starting from 1,3-dihydroxyacetone and evaluated for antiviral activity. Among compounds tested, amino substituted apio dideoxynucleosides exhibited anti-HBV activity, while thioapio dideoxynucleosides were found to be active against HIV-1. Apio dideoxydidehydro nucleosides showed moderate to potent anti-HCMV activity, but their bioisosteric thioapio dideoxydidehydro nucleosides did not exhibit any significant antiviral activity. |
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