Inactivation of S-adenosyl-L-homocysteine hydrolase with fluorinated analogs of 2'- and 3'-deoxy-5'-methylthioadenosine |
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| Authors: | Guillerm D Guillerm G Witkowski-Vandenplas C |
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| Institution: | Laboratoire des Réactions Sélectives et Applications-UMR 6519, Université de Reims, BP 1039, 51687 Reims, France. |
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| Abstract: | Fluorinated analogs of 2'- and 3'-deoxy-5'-methylthioadenosine 1-4 caused irreversible inactivation of AdoHcy hydrolase. Based on the ESI-Mass spectra analysis of the inactivated enzyme with the fluorinated analog 1 a mechanism of inactivation is proposed. |
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