Retinopathy of prematurity (ROP) and indomethacin therapy in premature infants with paten ductus arterious (PDA) |
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Authors: | TF Yeh MD D Raval MD S Pyati MD S Pildes MD |
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Institution: | From the Division of Neonatology, Cool County Children''s Hospital and The University of Illinois, College of Medicine, USA |
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Abstract: | Recent studies suggested that prostaglandins (PGs) may play a role in the pathogenesis of retinopathy of prematuriry (ROP). To evaluate if PGs inhibitor, indomethacin, would affect the incidence or severity of the ble-blind controlled study of indomethacin for the closure of PDA. Twenty-three were in the control group and 24 in the indometchin group. Indirect ophthalmospic examinations wee performed from about 4 weeks of postnatal age and onward and needed. There was no significant differences between the groups with respect to birth weight, gestational age, postnatal age, Apgar score, and cardiopulmonary status shortly after birth and at the time of study.Six in the control and 2 in the indomethacin group (p=0.58) developed active ROP; one in each group developed cicatricial ROP. It appears that with current doses of therapy, indomethacin does not increase the incidence or severity of ROP. |
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Keywords: | Reprint address: Division of Neonatology Cook County Children's Hospital 700 South Wood Street Chicago Illinois 60612 |
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