| 衰老大鼠的某些脑区组织中游离氨基酸水平的改变 |
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| 引用本文： | 殷伟平,蒋滢,蒋菊香,王尉平.衰老大鼠的某些脑区组织中游离氨基酸水平的改变[J].氨基酸和生物资源,2001,23(4):36-38. |
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| 作者姓名： | 殷伟平 蒋滢 蒋菊香 王尉平 |
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| 作者单位： | 1. 苏州大学医学院,江苏,苏州,215007
2. 苏州大学生命科学学院 |
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| 摘 要： | 使用D 半乳糖建立衰老大鼠模型组与同龄、同饲的正常对照组大鼠的某些脑区游离氨基酸 (FAA)水平的比较发现 :( 1 )衰老模型组的海马、纹状体以及皮层等脑区中谷氨酸 (Glu)、天门冬氨酸 (Asp)水平明显降低 ;( 2 )γ 氨基丁酸 (GABA)水平在衰老模型组大鼠的海马 ,纹状体以及小脑等脑区中明显升高 ;( 3)衰老模型组的皮层、小脑、海马、纹状体等脑区的牛磺酸 (Tau)水平明显下降。以此探讨动物衰老与脑区游离氨基酸水平的关系
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| 关 键 词： | 衰老 脑区 游离氨基酸 |
| 文章编号： | 1006-8376(2001)04-0036-03 |
| 修稿时间： | 2001年7月26日 |
Changes of Free Amino Acid Levels in Different Brain Regions of Aging Rats |
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| YIN Wei-ping ,JIANG Ying ,JIANG Ju-xiang ,WANG Wei-ping.Changes of Free Amino Acid Levels in Different Brain Regions of Aging Rats[J].Amino Acids & Biotic Resources,2001,23(4):36-38. |
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| Authors: | YIN Wei-ping JIANG Ying JIANG Ju-xiang WANG Wei-ping |
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| Institution: | YIN Wei-ping 1,JIANG Ying 1,JIANG Ju-xiang 2,WANG Wei-ping 2 |
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| Abstract: | Wistar's rats were injected with D-galactose to construct a aging animal model. Then the free amino acid levels in certain brain regions of the aging model were compared with control group. The results showed: (1)Glu and Asp levels of hippocampus(hipp.), striatum(str.) and cortex(cort.) decreased obviously in aging model; (2)GABA level of hippocampus, striatum and cerebellum(cerebell.) regions increased apparently in aging model; (3)taurine level of cerebellum, hippocampus, striatum and cortex decreased obviously in aging model group. |
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| Keywords: | aging brain region free amino acid |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
