| 元素衡算和代谢衡算在金色链霉菌培养过程的应用研究 |
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| 引用本文： | 扶教龙 庄英萍 黄明志 储炬 张嗣良. 元素衡算和代谢衡算在金色链霉菌培养过程的应用研究[J]. 生物工程学报, 2003, 19(4): 471-475 |
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| 作者姓名： | 扶教龙 庄英萍 黄明志 储炬 张嗣良 |
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| 作者单位： | 华东理工大学生物反应器工程国家重点实验室,上海,200237 |
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| 基金项目： | 上海市曙光计划基金资助 (No.0 1SG2 8)~~ |
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| 摘 要： | 应用元素衡算和代谢衡算方法，建立了金色链霉菌培养过程的数学模型。利用非线性优化方法对模型中的未知参数进行了估算，第一次得到了金霉素（CTC）生物合成的能量系数为1.8～2.8（molATP·C-mol－1）。应用该模型对CTC发酵过程中的几个宏观反应进行了预测，并与实验值进行了比较。结果表明，该模型较好地描述了各个宏观反应速率之间的关系，为CTC发酵过程优化提供了理论指导。
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| 关 键 词： | 元素衡算和代谢衡算， 金色链霉菌， 金霉素， 发酵 |
| 文章编号： | 1000-3061(2003)04-0471-05 |
| 修稿时间： | 2002-12-12 |
Application of Element and Metablism Balancing for the Cultivation Process with Streptomyces aureofaciens |
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| FU Jiao-Long ZHUANG Ying-Ping HUANG Ming-Zhi CHU Ju ZHANG Si-Liang. Application of Element and Metablism Balancing for the Cultivation Process with Streptomyces aureofaciens[J]. Chinese journal of biotechnology, 2003, 19(4): 471-475 |
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| Authors: | FU Jiao-Long ZHUANG Ying-Ping HUANG Ming-Zhi CHU Ju ZHANG Si-Liang |
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| Affiliation: | State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China. |
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| Abstract: | On the base of element and metablism balancing, the mathematical model of the cultivation process with Streptomyces aureofaciens was developed, and the unknown parameters in the model were estimated with the method of nonlinear optimization. Firstly the energetic coefficient of CTC biosynthesis was gained, which was 1.8 - 2.8 mol-ATP x C-mol(-1). The macroscopic reaction rates were predicted in the process and compared with the experimental values. The results show that the model can preferably describe the relationships between several macroscopic reaction rates in the process and can supervise the optimization of CTC fermentation process theoretically. |
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| Keywords: | element balancing and metablism balancing Streptomyces aureofaciens Chlorotetracycline fermentation |
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