Chromosomal imbalances are associated with metastasis-free survival in breast cancer patients. |
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| Authors: | Michaela Aubele Gert Auer Herbert Braselmann J?rg N?hrig Horst Zitzelsberger Leticia Quintanilla-Martinez Jan Smida Axel Walch Heinz H?fler Martin Werner |
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| Institution: | GSF - Research Center for Environment and Health, Institute of Pathology, D-85764 Neuherberg, Germany. aubele@gsf.de |
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| Abstract: | Multiple chromosomal imbalances have been identified in breast cancer using comparative genomic hybridization (CGH). Their association with the primary tumors' potential for building distant metastases is unknown. In this study we have investigated 39 invasive breast carcinomas with a mean follow-up period of 99 months (max. 193 months) by CGH to determine the prognostic value of chromosomal gains and losses.The mean number of chromosomal imbalances per tumor was 6.5+/-0.7 (range 2 to 18). The most frequent alterations identified in more than 1/3 of cases were gains on chromosomes 11q13, 12q24, 16, 17, and 20q, and losses on 2q and 13q. A significantly different frequency of chromosomal aberrations (p
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