PASS2: an automated database of protein alignments organised as structural superfamilies |
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| Authors: | Anirban?Bhaduri Ganesan?Pugalenthi Email author" target="_blank">Ramanathan?SowdhaminiEmail author |
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| Institution: | (1) National Centre for Biological Sciences, Tata Institute of Fundamental Research, UAS-GKVK campus, Bellary Road, Bangalore, Karnataka, 560 065, India |
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| Abstract: | Background The functional selection and three-dimensional structural constraints of proteins in nature often relates to the retention
of significant sequence similarity between proteins of similar fold and function despite poor sequence identity. Organization
of structure-based sequence alignments for distantly related proteins, provides a map of the conserved and critical regions
of the protein universe that is useful for the analysis of folding principles, for the evolutionary unification of protein
families and for maximizing the information return from experimental structure determination. The Protein Alignment organised
as Structural Superfamily (PASS2) database represents continuously updated, structural alignments for evolutionary related,
sequentially distant proteins. |
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