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Efficacy of mycobacterial components in the immunotherapy of mice with pulmonary tumor deposits
Authors:S Sukumar  J T Hunter  E Yarkoni  H J Rapp  B Zbar  E Lederer
Institution:(1) Laboratory of Immunobiology, National Cancer Institute, NIH, 20205 Bethesda, Maryland, USA;(2) Laboratoire de Biochemie, Centre National de la Recherche Scientifique, F-91190 Gif-sur-Yvette, France
Abstract:Summary The effectiveness of each of two mycobacterial components and a synthetic analog of one of them in the eradication of pulmonary deposits of intravenously injected syngeneic fibrosarcoma 1023 in C3H mice was studied. BCG cell walls (BCG CW), trehalose 6,6prime-dimycolate (TDM) or 6,6prime-di-0-2-tetradecyl, 3-hydroxyoctadecanoyl-agr,agr-trehalose (C76), a synthetic analog of TDM, was administered in emulsified form by three different routes: intraperitoneal, intradermal, or intravenous, 24 h after intravenous injection of 1023 tumor cells. The most effective form of therapy was TDM given by the intraperitoneal route; about 50% of treated animals were cured. Higher doses of BCG CW or C76 also led to a significant number of cures. Each agent caused a significant prolongation of survival time of the treated mice at two or more of the dosages tested; however, their routes of optimal activity varied.
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