| Nampt基因表达调控机制 |
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| 引用本文： | 黄锐,王子茹,孙宇,张刚,鲁亚平.Nampt基因表达调控机制[J].遗传,2012,34(12):1561-1569. |
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| 作者姓名： | 黄锐 王子茹 孙宇 张刚 鲁亚平 |
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| 作者单位： | 1. 安徽师范大学生命科学学院, 芜湖 241000 2. 复旦大学上海医学院药理学系, 上海 200032 |
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| 基金项目： | 安徽高校省级自然科学研究重大项目(编号:ZD2008006-1);生物化学与分子生物学省级重点学科项目资助 |
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| 摘 要： | 烟酰胺磷酸核糖转移酶(NAMPT)是烟酰胺腺嘌呤二核苷酸(NAD)生物合成途径的关键限速酶, 也被称为内脏脂肪素(Visfatin)或前B细胞克隆增强因子(PBEF)。它通过调节机体或细胞的NAD水平以及通过其他非酶机制等途径影响代谢、炎症反应、细胞的增殖、分化和凋亡, 特别是衰老等诸多过程。文章简要综述了近年来Nampt基因的表达调控及其转录的反馈调节机制研究进展。
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| 关 键 词： | Nampt基因 表达调控 反馈调节 |
| 收稿时间： | 2012-03-07 |
Mechanism of Nampt gene expression regulation |
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| HUANG Rui,WANG Zi-Ru,SUN Yu,ZHANG Gang,LU Ya-Ping.Mechanism of Nampt gene expression regulation[J].Hereditas,2012,34(12):1561-1569. |
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| Authors: | HUANG Rui WANG Zi-Ru SUN Yu ZHANG Gang LU Ya-Ping |
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| Institution: | 1. College of Life, Anhui Normal University, Wuhu 241000, China 2. Department of Pharmacology, Shanghai Medical College, Fudan University, Shanghai 200032, China |
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| Abstract: | Nicotinamide phosphoribosyltransferase (NAMPT), also known as pre-B cell colony-enhancing factor (PBEF) or visfatin, is a crucial rate-limiting enzyme of NAD biosynthetic pathway. It may affect the metabolism, inflammatory response, cell proliferation, differentiation, and apoptosis, especially the aging and other physiological progresses through regulating NAD biosynthesis and nonenzyme routes in the organisms and cells. This review mainly focuses on recent progresses in the expression modulation and feedback regulation of Nampt gene. |
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