The molecular basis for cold agglutination: effect of receptor density upon thermal amplitude of a cold agglutinin. |
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Authors: | C M Tsai D A Zopf V Ginsburg |
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Institution: | National Institute of Arthritis, Metabolism, and Digestive Diseases National Institutes of Health, Bethesda, Maryland 20014 USA |
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Abstract: | Cold agglutinin MKV is a Waldenström macroglobulin that agglutinates human erythrocytes in the cold by binding -acetylneuraminosyl-containing carbohydrate chains on their surfaces. Neuraminidase-treated cells are not agglutinated but their reactivity can be restored by allowing them to adsorb hematoside (NeuNAcα2-3Galβ1-4Glcβ1-ceramide). When between 7 × 104 and 106 molecules are adsorbed per cell, the cells are agglutinated at 0° but not at 37°. When over 106 molecules of hematoside are adsorbed, they are agglutinated at both 0° and 37°. The density of receptors on the erythrocyte surface can thus influence the thermal amplitude of cold agglutinins. |
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