Synthesis and in vitro antitubercular activity of 4-aryl/alkylsulfonylmethylcoumarins as inhibitors of Mycobacterium tuberculosis |
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| Authors: | Jeyachandran Malaichamy Ramesh Penugonda Sriram Dharmarajan Senthilkumar Palaniappan Yogeeswari Perumal |
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| Institution: | Post Graduate and Research Department of Chemistry, Sri Paramakalyani College, Alwarkurichi, Tirunelveli 627 412, Tamil Nadu, India. |
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| Abstract: | A series of 4-aryl/alkylsulfonylmethylcoumarins have been synthesized and screened for in vitro antitubercular activity against Mycobacterium tuberculosis H(37)Rv (MTB). Four of the compounds showed MIC in the range of 0.78-3.13 μg/mL proving their potential activity. |
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