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Mutational analysis of cutaneous squamous cell carcinomas and verrucal keratosis in patients taking BRAF inhibitors |
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| Authors: | Anforth Rachael Tembe Varsha Blumetti Tatiana Fernandez-Peñas Pablo |
| Affiliation: | 1. Department of Dermatology, Westmead Hospital, Sydney, NSW, Australia;2. Sydney Medical School, The University of Sydney, Sydney, NSW, Australia;3. Westmead Millennium Institute for Medical Research, Sydney, NSW, Australia |
| Abstract: | B-RAF inhibitors (BRAFi) have been shown to improve rates of overall and progression-free survival in patients with stage IV metastatic melanoma positive for the BRAF V600E mutation. However, the main drawback is the development of verrucal keratosis (hyperkeratotic papules with verruca-like characteristics with benign histological findings) and cutaneous squamous cell carcinomas (cuSCC). We have found upstream mutations in RAS as well as PIK3CA in both verrucal keratosis and cuSCC. This suggests that verrucal keratosis is an early clinical presentation of cuSCC in patients on BRAFi. |
| Keywords: | melanoma BRAF inhibitors squamous cell carcinoma verrucal keratosis |
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