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Synthesis and antimalarial activity of calothrixins A and B, and their N-alkyl derivatives |
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| Authors: | Matsumoto Kohji Choshi Tominari Hourai Mai Zamami Yoshito Sasaki Kenji Abe Takumi Ishikura Minoru Hatae Noriyuki Iwamura Tatsunori Tohyama Shigeo Nobuhiro Junko Hibino Satoshi |
| Institution: | Graduate School of Pharmacy & Pharmaceutical Sciences, and Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima 729-0292, Japan. |
| Abstract: | We synthesized calothrixin B using our developed biomimetic method and derived N-alkyl-calothrixins A and B. The in vitro antimalarial activity of the calothrixin derivatives, including calothrixins A and B, against the Plasmodium falciparum FCR-3 strain was evaluated. All test compounds exhibited antimalarial activity over a concentration range of 6.4×10(-6)-1.2×10(-7) M. |
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