| 神经生长因子受体Trka在糖尿病大鼠膀胱和腰骶背根神经节的表达 |
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| 引用本文： | 李月峰,郭跃先,高景宇.神经生长因子受体Trka在糖尿病大鼠膀胱和腰骶背根神经节的表达[J].中国组织化学与细胞化学杂志,2008,17(3):319-322. |
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| 作者姓名： | 李月峰 郭跃先 高景宇 |
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| 作者单位： | 1. 河北省邯郸市第一医院泌尿外科,河北,056002
2. 河北医科大学第三医院泌尿外科,石家庄,050001 |
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| 摘 要： | 目的研究糖尿病大鼠膀胱组织及背根神经节中神经生长因子受体Trka的表达变化及意义。方法建立糖尿病大鼠模型20只,以15只正常大鼠为对照,应用免疫组化方法,分别检测大鼠膀胱组织及背根神经节中Trka的表达情况。结果无论是在膀胱组织还是在背根神经节中,糖尿病组Trka的表达均低于对照组,差异有统计学意义（P〈0.01）。结论神经生长因子受体Trka的表达降低与糖尿病膀胱病变的发生有关。
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| 关 键 词： | 糖尿病 膀胱疾病 背根神经节 Trka |
EXPRESSION OF NGF RECEPTOR Trka IN LUMBAR DORSAL ROOT GANGLIA AND BLADDER OF STREPTOZOCIN-INDUCED DIABETIC RATS |
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| Li Yuefeng,Guo Yuexian,Gao Jingyu.EXPRESSION OF NGF RECEPTOR Trka IN LUMBAR DORSAL ROOT GANGLIA AND BLADDER OF STREPTOZOCIN-INDUCED DIABETIC RATS[J].Chinese Journal of Histochemistry and Cytochemistry,2008,17(3):319-322. |
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| Authors: | Li Yuefeng Guo Yuexian Gao Jingyu |
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| Institution: | Li Yuefeng1,Guo Yuexian2,Gao Jingyu2(1Department of Urological Surgery,The First Hospital of H,an City of Hebei Province,Hebei 056002,2Department of Urological Surgery,The Third Hospital of Hebei Medical University,Shijiazhuang 050001,China) |
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| Abstract: | Objective To investigate the expression of Trka in lumbar dorsal root ganglia(DRG) and bladder of streptozocin-induced diabetic rats,then clarify the factor's role in diabetic cystopathy(DC),and supply experimental data for the clinical and fundamental study on DC.Methods In 20 of the diabetes model rats and 15 normal control,Trka was measured in bladder and DRG by immunohistochemical staining.Results The Trka levels in both bladder and DRG of the diabetes mellitus group were lower than those in the control... |
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| Keywords: | Diabetes mellitus Bladder disease Dorsal root ganglion Trka |
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