Effect of sun ginseng methanol extract on lipopolysaccharide-induced liver injury in rats |
| |
Authors: | K.S. Kang N. Yamabe H.Y. Kim T. Yokozawa |
| |
Affiliation: | aInstitute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan |
| |
Abstract: | Sun ginseng (SG) is heat-processed Panax ginseng C.A. Meyer steamed at 120 °C, which has ginsenoside-Rg3, -Rk1, and -Rg5 as its main ginsenoside components. The effect of SG on lipopolysaccharide (LPS)-induced liver injury in rats was investigated in this study. Intravenous injection of LPS induced excessive nitric oxide (·NO) generation in serum and increased the hepatic mitochondrial thiobarbituric acid-reactive substance (TBA-RS) level. However, the elevated TBA-RS level was significantly lowered by 15 consecutive days of SG administrations. In addition, up-regulated hepatic inducible nitric oxide synthase and heme oxygenase 1 levels in LPS-treated control rats were significantly lowered and increased, respectively, by 100 mg/kg body weight/day of SG administration. These antioxidant effects were thought to be partially related to the deactivation of nuclear factor-κB by SG administration. |
| |
Keywords: | Panax ginseng Lipopolysaccharide Nitric oxide Nuclear factor-κB |
本文献已被 ScienceDirect 等数据库收录! |
|