The inhibition of in vivo tumorigenesis of osteosarcoma (OS)-732 cells by antisense human osteopontin RNA |
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| Authors: | Si-Jin Liu Dao-Qiang Zhang Xiu-Mei Sui Lin Zhang Zi-Wei Cai Li-Qiu Sun Ya-Jun Liu Yan Xue Guo-Fa Hu |
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| Institution: | (1) Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100080, China;(2) Wendeng Central Hospital, Weifang Medical College, Weihai, Shandong Province, 264400, China;(3) Research Institute of Sports Medicine, Soochow University, Suzhou, Jiangsu Province, 215021, China;(4) Department of Pathophysiology, Medical College of Shantou University, Shantou, 515031, China;(5) Beijing Jishuitan Hospital, Peking University, Beijing, 100035, China;(6) Present address: Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 45 Carleton Str, E25-537, Cambridge, MA 02142, USA |
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| Abstract: | Osteopontin (OPN) is a secreted, non-collagenous, sialic acid-rich protein which functions by mediating cell-matrix interactions
and cellular signaling via binding with integrins and CD44 receptors. An increasing number of studies have shown that OPN
plays an important role in controlling cancer progression and metastasis. OPN was found to be expressed in many human cancer
types, and in some cases, its over-expression was shown to be directly associated with poor patient prognosis. In vitro cancer cell line and animal model studies have clearly indicated that OPN can function in regulating the cell signaling that
ultimately controls the oncogenic potential of various cancers. Previous studies in our laboratory demonstrated that OPN is
highly expressed in human osteosarcoma (OS) cell line OS-732. In this study, we successfully reduced the tumorigenecity of
OS-732 cells xenotransplanted into nude mice, using the antisense human OPN (hOPN) RNA expression vector. |
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| Keywords: | Osteopontin Osteosarcoma Antisense RNA |
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