N-t-Boc-amino acid esters of isomannide Potential inhibitors of serine proteases |
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| Authors: | E M F Muri M Gomes Jr J S Costa F L Alencar A Sales Jr M L Bastos R Hernandez-Valdes M G Albuquerque E F F da Cunha R B Alencastro J S Williamson O A C Antunes |
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| Institution: | (1) Instituto de Química, UFRJ, Cidade Universitária, CT Bloco A, Rio de Janeiro, Brazil;(2) Núcleo de Pesquisas de Produtos Naturais, UFRJ, Cidade Universitária, CCS Bloco H, Rio de Janeiro, Brazil;(3) Faser Hall, School of Pharmacy, Department of Medicinal Chemistry, University of Mississippi, Mississippi, U.S.A. |
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| Abstract: | Summary. Hepatitis C, Dengue and West Nile virus are some of the most important flaviviruses, that share one important serine protease enzyme. Serine proteases are the most studied class of proteolytic enzyme and, in these cases, a primary target for drug discovery. In this paper, we describe the synthesis and preliminary molecular modeling studies of a novel class of N-t-Boc amino acid esters derived of isomannide as potential serine proteases inhibitors. |
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| Keywords: | : Isomannide derivatives – Serine protease – Dengue virus |
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