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Studies on the reactivity of organometallic Ru-, Rh- and Os-pta complexes with DNA model compounds |
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| Authors: | Dorcier Antoine Hartinger Christian G Scopelliti Rosario Fish Richard H Keppler Bernhard K Dyson Paul J |
| Affiliation: | aInstitut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland bInstitute of Inorganic Chemistry, University of Vienna, Waehringer Street 42, A-1090 Vienna, Austria cLawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA |
| Abstract: | The reactions of arene–metal complexes (arene = p-cymene, benzene or pentamethylcyclopentadienyl, metal = Ru, Rh or Os), including 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decanephosphine (pta) and chloro co-ligands, with 9-methylguanine, adenine, and a series of nucleosides were studied in water to ascertain the binding modes. The products were characterized by NMR spectroscopy and electrospray ionization mass spectrometry (ESI-MS). Tandem mass spectrometry was found to provide excellent information on preferential binding sites. In general, the N7 position on guanine (the most basic site) was found to be the preferred donor atom for coordination to the metal complexes. The X-ray structures of the precursor complexes, [(η5-C10H15)RhCl(pta-Me)2]Cl2, [(η6-C10H14)OsCl(pta)2]Cl, and [(η6-C6H6)OsCl2(CH3CN)], are also reported. |
| Keywords: | Anticancer drugs DNA binding Electrospray ionization mass spectrometry pta Arene–ruthenium complexes Bioorganometallic chemistry |
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