CDKN2A is a prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma |
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| Authors: | Jun-peng Luo Jing Wang Jin-hua Huang |
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| Institution: | 1.Department of Minimally Invasive Interventional Therapy, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Cancer for Cancer Medicine, 651 Dongfeng Road East, Guangzhou 510060, Guangdong Province, People’s Republic of China;2.Department of General Medicine, the First Medical Center, Department of Chinese PLA General Hospital, Beijing, China |
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| Abstract: | Cyclin dependent kinase inhibitor 2A (CDKN2A) is an essential regulator of immune cell functionality, but the mechanisms whereby it drives immune infiltration in hepatocellular carcinoma (HCC) remain unclear. In the present study, we studied the association with CDKN2A expression and immune invasion with the risk of developing HCC. A totally of 2207 different genes were found between HCC and adjacent liver tissues from TCGA and GEO databases. CDKN2A was highly expressed in HCC and associated with poorer overall survival and disease-free survival. Notably, CDKN2A expression was positively correlated with infiltrating levels into purity, B cell, CD+8 T cell, CD+4 T cell, macrophage, neutrophil, and dendritic cells in HCC. CDKN2A expression showed strong correlations between diverse immune marker sets in HCC. These findings suggest that CDKN2A expression potentially contributes to regulation of tumor-associated macrophages and can be used as a prognostic biomarker for determining prognosis and immune infiltration in HCC. |
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| Keywords: | CDKN2A Hepatocellular carcinoma Immune signature Prognostic biomarker Survival Tumor-infiltrating |
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