Studies on a strain of Fusarium solani (Mart.) Sacc. Isolated from a case of mycotic keratitis |
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| Authors: | Seema Wahab B. Lal Z. Jacob V. C. Pandey O. P. Srivastava |
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| Affiliation: | (1) Fermentation Technology Division, Central Drug Research Institute, Lucknow, India;(2) Biochemistry Division, Central Drug Research Institute, Lucknow, India;(3) Ophthalmology Department, King George's Medical College, Lucknow, India |
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| Abstract: | A strain of Fusarium solani (Mart.) Sacc. (IMI-216517), isolated from a patient of mycotic keratitis, produced experimental keratomycosis in albino rabbit cornea and survived in internal tissues of albino mice for varying periods. Alantolactone, isolated from the plant — Inula racemosa Hook. f. exhibited marked in vitro fungistatic activity against this strain of F. solani at 100–200  g/ml concentrations. The strain was less sensitive to amphotericin B and showed more acid than alkaline proteinase and phosphatase activities.Communication No. 2526. |
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