Effect of different doses of GLP-2 (Teduglutide) on acute esophageal lesion due to acid-pepsin perfusion in male rats |
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| Authors: | Moloudi Rohallah Nabavizadeh Fatemeh Nahrevanian Hossein Hassanzadeh Gholamreza |
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| Institution: | aDepartment of Physiology, Tehran University of Medical Sciences, Tehran, Iran;bDepartment of Parasitology, Pasteur Institute of Iran, Tehran, Iran;cDepartment of Anatomy, Tehran University of Medical Sciences, Tehran, Iran |
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| Abstract: | Gastro-esophageal reflux currently is widespread disorders with dangerous complications. GLP-2 is a peptide that has trophic and anti-inflammatory effects on gastrointestinal mucosa. The aim of this study was to evaluate the protective role of GLP-2 in esophageal mucosa lesion due to perfusion acid-pepsin. Thirty-six male rats were used in this study and divided into six groups. They were control, acid-pepsin, GLP-2 20 μg, GLP-2 30 μg, GLP-2 40 μg and GLP-2 50 μg/kg groups. Esophageal blood flow, plasma NO metabolite, esophageal tissue NO metabolites and histological study of esophagus were performed as indicators of esophageal damage following acid-pepsin perfusion. Results showed that GLP-2 significantly increased plasma and tissue NO metabolites in comparison to acid-pepsin group. Also histological study showed significantly fewer lesions in the most effective dose GLP-2 30 μg in comparison to acid-pepsin group, our results show that GLP-2 could be useful for the treatment of esophageal in animal model. |
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| Keywords: | GLP-2 (Teduglutide) Gastro esophageal reflux Nitric oxide Blood flow Mucous membrane |
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