胃异型增生及胃癌核仁组成区嗜银蛋白定量研究

应用核仁组成区嗜银蛋白(AgNOR)技术对100例胃切除标本(胃癌50例,异型增生30例,正常胃20例)观察研究。结果核内AgNOR均数在胃异型增生、胃癌中增多与正常胃上皮细胞有显著差异(P<0.001),且嗜银颗粒逐渐变大,变分散。在胃癌的不同类型、分化程度、浸润深度、有无淋巴结转移及术后存活时间长短之间亦均有显著差异。提示AgNOR技术对于胃癌、癌前病变的诊断、胃癌的分型、分级及估价预后都有一定的实用价值。

QUANTITATIVE STUDY ON AgNOR OF GASTRIC ATYPICAL HYPERPLASIA AND GASTRIC CARCINOMA

100 Cases of gastrectomy biopsy (50 cases of gastric carcinoma, 30 of gastric atypical hyperplasia and 20 of normal stomach) were quantitatively studied by using the tehnique of argyrophilic nucleolar organizer region (AgNOR). The result showed that AgNOR mean/karyon was increased in gastric atypical hyperplasia and gastric carcinoma with significant difference from normal gastric tissues (P<0.001). The AgNOR granules became gradually enlarged and divergent and there were marked difference in the variety of types, degree of diffferentiation, depth of infiltration, the presence or absence of lymph node metastasis and postoperative prognosis. What we have seen above suggests AgNOR technique is of great value in the diagnosis of gastric carcinoma and atypical hyperplasia, as well as in the typing, gradation and prognosis evaluation of gastric carcinoma.