Local cerebral glucose utilization in the Ammon's horn and dentate gyrus of the rat brain |
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| Authors: | A Wree A Schleicher K Zilles T Beck |
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| Institution: | (1) Anatomisches Institut der Universität zu Köln, Joseph-Stelzmann-Strasse 9, D-5000 Köln 40, Federal Republic of Germany;(2) Institut für Pharmakologie und Toxikologie, Fachbereich Pharmazie und Lebensmittelchemie der Universität Marburg, D-3550 Marburg, Federal Republic of Germany;(3) Present address: Department of Anatomy, University of Würzburg, Koellikerstr. 6, D-8700 Würzburg, Federal Republic of Germany |
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| Abstract: | Summary The local cerebral glucose utilization (LCGU) was measured in different regions and layers of the Ammon's horn and dentate gyrus in the conscious rat. The LCGU was determined by quantitative 14C]2-deoxyglucose autoradiography using a computerized image processing system.In the hippocampus, the various regions and layers exhibited different glucose consumptions, the lowest values being found in the alveus and the highest ones in the lacunosum-molecular layers of the dentate gyrus' external limb. Additionally, in many layers, the LCGU values of the left hemispheres were found to be higher compared with the right hemispheres. The analysis of LCGU changes in rostrocaudal direction revealed, that in sector 1 of Ammon's horn and in the dentate gyrus the glucose consumption decreased from rostral to caudal levels, whereas in sector 3 of Ammon's horn an increase was found.Dedicated to Professor Dr. T.H. Schiebler on the occasion of his 65th birthday |
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