New neuritogenic steroidal saponin from Ophiopogon japonicus (Thunb.) Ker-Gawl |
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| Authors: | Qu Yuan Zhang Yang Pei Liang Wang Yan Gao Lijuan Huang Qianming Ojika Makoto Sakagami Youji Qi Jianhua |
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| Institution: | College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. |
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| Abstract: | A new steroidal saponin was isolated from Ophiopogon japonicus. This saponin possesses a modification by 2-hydroxy-3-methylvalerylation of the hydroxyl group at C-4' of the sugar, linked to C-1 of the aglycone. It exhibited significant neuritogenic activity for PC12 cells. The structure-activity relationship revealed the aglycone, rather than the sugar moieties and acylation, to be important for the neuritogenic activity. |
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