磷酯酰肌醇-4-磷酸与丙肝病毒相互关系的研究进展

丙型肝炎由丙肝病毒(hepatitis C virus,HCV)引起,流行性很强。HCV主要通过毒品注射、输血或器官移植传播;极少数情况下,HCV通过血透析、母婴垂直传染。少部分感染HCV的患者会产生急性丙型肝炎,而大多数人会转变成慢性肝炎,其中1/3的人群病情逐渐恶化,严重时导致肝癌。除了肝脏病变,HCV感染还会引起其他组织和器官的损害。因此,对于HCV感染机制的研究显得尤为重要。近年来,寻找参与HCV复制的关键性宿主因子已成为研究热点,磷酯酰肌醇-4-磷酸(phosphatidylinositol-4-phosphate,PI4P)就是其中之一。该文将着重介绍PI4P及相关蛋白参与HCV生命周期的研究进展,并简要总结相关的鞘脂和胆固醇的生理功能。

Interplay between PI4P and Hepatitis C Virus

Hepatitis C is caused by Hepatitis C virus(HCV),and has strong epidemicity all over the world.The HCV is mainly spread by drug injection,blood-to-blood contact or organ transplantation.In rare case,HCV is spread through blood dialysis and maternal-infant vertical infection.Upon HCV infection,few patients get acute infection,whereas most of the patients turn to chronic infection,and roughly one-third progress to live cirrhosis in less than 20 years,some of whom will get cancer.In addition to liver lesions,HCV infection can also cause damage to other tissues and organs.Thus,exploring the underlying mechanism of HCV infection is particularly important.In recent years,an emerging role for host factors including lipids in HCV infection has been discovered.Here,we discussed the recent progress of the role of PI4P and its associated proteins in HCV life cycle.The biological function of sphingomyelin and cholesterol is also briefly summarized in this review.