Human bitter taste receptors hTAS2R8 and hTAS2R39 with differential functions to recognize bitter peptides |
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| Authors: | Ueno Yohei Sakurai Takanobu Okada Shinji Abe Keiko Misaka Takumi |
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| Affiliation: | Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan. |
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| Abstract: | The strong bitter peptide, Phe-Phe-Pro-Arg, activated cultured cells expressing either of the known human bitter taste receptors, hTAS2R8 and hTAS2R39. The partial structure of Pro-Arg activated hTAS2R39, but did not activate hTAS2R8. These receptors may not indiscriminately recognize bitter peptides, but have a differential function in their recognition. |
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