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Minimum structural requirements for encephalitogen and for adjuvant in the induction of experimental allergic encephalomyelitis. |
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| Authors: | Y Nagai K Akiyama K Suzuki S Kotani Y Watanabe T Shimono T Shiba S Kusumoto F Ikuta S Takeda |
| Affiliation: | 1. Department of Biochemistry, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan;2. Tohoku College of Pharmaceutical Science, Sendai, Japan;3. Department of Microbiology, Osaka University Dental School, Osaka, Japan;4. Faculty of Science, Osaka University, Osaka, Japan;7. Brain Research Institute, Niigata University, Niigata, Japan |
| Abstract: | Mycobacteria in the adjuvant used for induction of experimental autoimmune encephalomyelitis (EAE) in guinea pigs can be replaced by synthetic N-acetylmuramyl-l-alanyl-d-isoglutamine. A combination of synthetic encephalitogenic peptides and muramyl dipeptides induces EAE effectively at a dose on the microgram level. In this system, the synthetic heptapeptide, H-Trp-Gly-Ala-Glu-Gly-Gln-Arg-OH, with a sequence identical to those of residues 116 to 122 of the basic protein of human myelin, was the shortest peptide causing EAE. These compounds form a simple system which should be useful in studies on the mechanism of the cell-mediated autoimmune reaction. |
| Keywords: | To whom correspondence and requests for reprints should be sent at the Department of Biochemistry Tokyo Metropolitan Institute of Gerontology 35-2 Sakaecho Itabashiku Tokyo-173 Japan. |
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