On the binding of aflatoxin B 1 and its metabolites to hepatic microsomes |
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| Authors: | H L Gurtoo |
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| Affiliation: | Department of Experimental Therapeutics Roswell Park Memorial Institute New York State Department of Health Buffalo, New York 14203 USA |
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| Abstract: | The metabolism of aflatoxin B1 was studied using the cytochrome P450-dependent mixed function oxidase system of rat liver microsomes. An aflatoxin metabolite produced in the presence of microsomes and NADPH and not produced in the presence of SKF-525A seems to become covalently bound to microsomes. The bound metabolite is observed as a spectral peak at 412 nm by means of difference spectroscopy. This metabolite appears to be related to either aflatoxin B2a or its precursor. |
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