Effects of starvation and refeeding on erythropoiesis in mice

Summary Erythropoiesis has been studied in the mouse following acute starvation and refeeding. Starvation produced a depression of erythropoiesis in both spleen and bone marrow. Refeeding, however, resulted in marked erythropoiesis in the spleen and relatively little erythropoiesis in the marrow. It is suggested that the spleen may be the primary organ in the mouse for the reestablishment of erythropoietic homeostasis.Dedicated to Professor B erta Scharrer with best personal wishes on the occasion of her 60th birthday.This study was supported by United States Public Health Service Grant No Ca-03071 Hem. from the National Cancer Institute.I wish to express my thanks to Mr. A. Scorza, Dept. of Pathology, for his excellent technical assistance in the preparation of the histological material.