Thymulin and the neuroendocrine system |
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Authors: | Goya Rodolfo G Brown Oscar A Pléau Jean-Marie Dardenne Mireille |
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Institution: | Faculty of Medicine, Institute for Biochemical Research at La Plata-Histology B, National University of La Plata, La Plata, Argentina. rgoya@netverk.com.ar |
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Abstract: | Thymulin is a thymic hormone exclusively produced by the thymic epithelial cells. It consists of a nonapeptide component coupled to the ion zinc, which confers biological activity to this molecule. After its discovery in the early 1970, thymulin was characterized as a thymic hormone involved in several aspects of intra- and extrathymic T-cell differentiation. Subsequently, it was demonstrated that thymulin production and secretion is strongly influenced by the neuroendocrine system. Conversely, an emerging core of information points to thymulin as a hypophysotropic peptide. Here we review the evidence supporting the hypothesis that thymulin is an important player in the hypophyso-thymic axis. |
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