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The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals |
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| Authors: | Carol A Edwards Willem Rens Oliver Clarke Andrew J Mungall Timothy Hore Jennifer A Marshall Graves Ian Dunham Anne C Ferguson-Smith Malcolm A Ferguson-Smith |
| Institution: | (1) Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK;(2) Cambridge Resource Centre for Comparative Genomics, Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 OES, UK;(3) Wellcome Trust Genome Campus, Hinxton, Wellcome Trust Sanger Institute, Cambridge, CB10 1SA, UK;(4) Research School of Biological Sciences, The Australian National University, Canberra, Australia |
| Abstract: | BackgroundThe evolution of genomic imprinting, the parental-origin specific expression of genes, is the subject of much debate. There are several theories to account for how the mechanism evolved including the hypothesis that it was driven by the evolution of X-inactivation, or that it arose from an ancestrally imprinted chromosome. |
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