Inhibitory activity spectrum of reuterin produced by <Emphasis Type="Italic">Lactobacillus reuteri</Emphasis> against intestinal bacteria |
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Authors: | Valentine Cleusix Christophe Lacroix Sabine Vollenweider Marc Duboux Gwenaelle Le Blay |
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Institution: | (1) Institute of Food Science and Nutrition, Laboratory of Food Biotechnology, Swiss Federal Institute of Technology, Zurich, Switzerland |
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Abstract: | Background Reuterin produced from glycerol by Lactobacillus reuteri, a normal inhabitant of the human intestine, is a broad-spectrum antimicrobial agent. It has been postulated that reuterin
could play a role in the probiotic effects of Lb. reuteri. Reuterin is active toward enteropathogens, yeasts, fungi, protozoa and viruses, but its effect on commensal intestinal bacteria
is unknown. Moreover reuterin's mode of action has not yet been elucidated. Glutathione, a powerful antioxidant, which also
plays a key role in detoxifying reactive aldehydes, protects certain bacteria from oxidative stress, and could also be implicated
in resistance to reuterin. |
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