Deficient repair of DNA lesions in Alzheimer's disease fibroblasts |
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Authors: | J C Li E Kaminskas |
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Affiliation: | Biochemistry Research Laboratory, Department of Biological Sciences, University of Keele, Keele, Staffordshire, ST5 5BG, U.K. |
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Abstract: | DNA strand breaks, resulting from treatment with N-methyl-N'-nitro-N-nitrosoguanidine, were repaired more slowly in four strains of familial Alzheimer's disease fibroblasts than in five strains of fibroblasts from age-matched normals. These results were not due to differences between the two cell types in in vitro ages, in the initial DNA damage or in drug-induced cell lysis. Bleomycin-induced DNA double-strand breaks were repaired equally efficiently by both types of cells. Alzheimer's disease cells may have a DNA repair defect, which may be involved in the pathogenesis of this disease. |
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