| 病毒唑对肾综合征出血热患者特异性抗体应答的影响 |
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| 引用本文： | 肖书渊,朱宝莲,张美英,郑志明,向近敏,J.M.Meegan,J.W.LeDuc,J.W.Huggins,T.Cosgriff,J.I.Smith. 病毒唑对肾综合征出血热患者特异性抗体应答的影响[J]. 病毒学报, 1987, 0(3) |
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| 作者姓名： | 肖书渊 朱宝莲 张美英 郑志明 向近敏 J.M.Meegan J.W.LeDuc J.W.Huggins T.Cosgriff J.I.Smith |
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| 作者单位： | 湖北医学院病毒研究所(肖书渊，朱宝莲，张美英，郑志明，向近敏)，美国陆军传染病研究所(J.M.Meegan，J.W.LeDuc，J.W.Huggins，T.Cosgriff)，美国陆军传染病研究所(J.I.Smith) |
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| 摘 要： | 在用病毒唑(Ribavirin)治疗肾综合征出血热(Hemorrhagic fever with renal syndrome,HFRS)(以安慰剂作对照)的双盲法临床试验中,用微量酶联免疫吸附技术对确诊的64例患者血清和尿液中特异性IgG及IgM抗体水平进行动态观察与分析,结果发现,病毒唑治疗组两种血清抗体水平均较安慰剂对照组低(IgG,P<0.001;IgM,P<0.05),而两组患者尿液中两种抗体水平与阳性率均无明显差异,表明病毒唑对HFRS患者抗体的生成具有抑制作作用,本文就该作用的原因与后果进行了分析评价。
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| 关 键 词： | 肾综合征出血热 病毒唑 酶联免疫吸附试验 血清抗体 |
EFFECT OF RIBAVIRIN ON THE SPECIFIC HUMORAL IMMUNE RESPONSES OF PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME |
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| Xiao Shuyuan Zhu Baolien Zhang Meiying Zheng Zhiming Xiang Jinmin J.M.Meegan J.W.LeDuc J.W. Huggins T.Cosgriff J.I. Smith Virus Research Institute of Hubei Medical CollegeThe United States Army Medical Research Institute of Infectious Disease. EFFECT OF RIBAVIRIN ON THE SPECIFIC HUMORAL IMMUNE RESPONSES OF PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME[J]. Chinese journal of virology, 1987, 0(3) |
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| Authors: | Xiao Shuyuan Zhu Baolien Zhang Meiying Zheng Zhiming Xiang Jinmin J.M.Meegan J.W.LeDuc J.W. Huggins T.Cosgriff J.I. Smith Virus Research Institute of Hubei Medical CollegeThe United States Army Medical Research Institute of Infectious Disease |
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| Affiliation: | Xiao Shuyuan Zhu Baolien Zhang Meiying Zheng Zhiming Xiang Jinmin J.M.Meegan J.W.LeDuc J.W. Huggins T.Cosgriff J.I. Smith Virus Research Institute of Hubei Medical CollegeThe United States Army Medical Research Institute of Infectious Disease |
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| Abstract: | In a double-blind, placebo-controlled clinical trial of ribavirin therapeutic efficacy in the treatment of hemorrhagic fever with renal syndrome(HF RS), the specific IgM and IgG antibodies to the causative agent, Hantaan virus,in 335 serum and 505 urine specimens from 64 patients were measured with en zymelinked immunosorbent assay. The results showed a significant decrease of serum antibody levels in the ribavirin-treated group as opposed to the placebo group in IgG (P<0.001) and in IgM (P<0.05). But the results obtained with the urine samples showed no significant difference of the IgG and IgM antibody levels, nor in the percentage of positive antibody detection between the two groups. The experiment suggests that ribavirin has an inhibitive effect on the HFRS patients' antibody responses and may reduce the formation of circular immune complexes which are supposed to be partly responsible for the pathogenesis of this disease. |
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| Keywords: | Hemorrbagic fever with renal syndrome Ribavirin Enzyme-linked immunosorbent assay Serum antibody |
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