Phenytoin protected mouse cortical cell cultures against neurotoxicity induced by kainate but not by NMDA |
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Authors: | H Furue N Fudamato Y Ohtubo K Yoshii PhD |
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Institution: | (1) Department of Biochemical Engineering and Science, Kyushu Institute of Technology, 820 Iizuka, Fukuoka, Japan |
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Abstract: | Summary Phenytoin (PHT) protected cultured mouse cortex neurons against kainate-induced excitotoxicity, but failed to protect against the N-methyl-D-aspartate (NMDA)-induced excitotoxicity. The voltage-clamp experiments showed that PHT significantly blocked kainate-induced currents but did not block NMDA-induced currents in the cultured neurons. These results indicate that PHT protects the cultures by blocking non-NMDA receptors and suggest that PHT has clinical efficacy against neuronal cell death through the excessive stimulation of non-NMDA receptors. |
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Keywords: | Amino acids Excitotoxicity Voltage clamp Diphenylhydantoin DPH PHT LDH |
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