Mapping of a Putative Tumor Suppressor Locus to Proximal 7p in Wilms Tumors |
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Authors: | Monica Miozzo Daniela Perotti Fabiola Minoletti Patrizia Mondini Silvana Pilotti Roberto Luksch Franca Fossati-Bellani Marco A Pierotti Gabriella Sozzi Paolo Radice |
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Institution: | aDivision of Experimental Oncology A, Istituto Nazionale Tumori, via G. Venezian 1, 20133, Milan, Italy;bDivision of Pediatric Oncology, Istituto Nazionale Tumori, via G. Venezian 1, 20133, Milan, Italy;cDivision of Anatomic Pathology and Citology, Istituto Nazionale Tumori, via G. Venezian 1, 20133, Milan, Italy |
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Abstract: | Different findings suggest that alterations of chromosome 7 genes play a role in the development of Wilms tumors. To define the positions of these genes, we have accomplished a combined cytogenetic and molecular study on 11 sporadic Wilms tumors. In one case, where both chromosomes 7 were rearranged, the karyotypic picture was consistent with the presence of a tumor suppressor gene at 7p15. To test this hypothesis, a loss of heterozygosity analysis was performed using microsatellite markers. This revealed a common region of allele losses mapped to the proximal short arm of chromosome 7 and defined the position of the gene(s) involved in Wilms tumors within an interval of approximately 25 cM. |
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