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| 小RNA病毒蛋白与细胞凋亡的关系 | |
| 引用本文： | 马晓霞,周建华,沈心亮.小RNA病毒蛋白与细胞凋亡的关系[J].生物技术通讯,2009,20(1):103-105. |
| 作者姓名： | 马晓霞 周建华 沈心亮 |
| 作者单位： | 1. 兰州大学,生命科学院,甘肃,兰州,730000;中国农业科学院,兰州兽医研究所,甘肃,兰州,730046;北京生物制品研究所,北京,100024 2. 中国农业科学院,兰州兽医研究所,甘肃,兰州,730046 3. 北京生物制品研究所,北京,100024 |
| 摘 要： | 很多小RNA病毒科病毒感染宿主细胞后可引发宿主细胞凋亡，这种现象被认为是宿主细胞对抗小RNA病毒侵染的防御机制。凋亡机制可由某些病毒蛋白对细胞产生信号干扰来实现多种凋亡通路。虽然这些凋亡通路的上游事件是不同的，但最后的效应却很一致。此外，一些病毒蛋白具有抑制细胞凋亡的功能，它们能够令感染病毒后的细胞不死亡，形成病毒与宿主细胞共存的持续性感染状态。 |
| 关 键 词： | 小RNA病毒 细胞凋亡 持续性感染 |
Picornaviruses Proteins and Apoptosis |
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| MA Xiao-Xia,ZHOU Jian-Hua,SHEN Xin-Ling.Picornaviruses Proteins and Apoptosis[J].Letters in Biotechnology,2009,20(1):103-105. | |
| Authors: | MA Xiao-Xia ZHOU Jian-Hua SHEN Xin-Ling |
| Affiliation: | 1.School of Life Science, Lanzhou University, Lanzhou 730000; 2. Lanzhou Veterinary Research Institute, Chinese Academy of Agriculture Science, Lanzhou 730046; 3. National Vaccine and Serum Insititute, Beijing 100024, China) |
| Abstract: | Infection of cells with a variety of picornaviruses elicits a defensive response in the form of apoptotic death. The apoptotic death machinery including cross-talking, various regulated pathways may be triggered by some picornaviral proteins. Although the upstream steps of these pathways are different, the final outcome is strikingly uniform. On the contrary, some picornaviral proteins inhibit apoptosis, enable infection-cells not to die, and to form persistent infection. As a result, picornaviruses can exist in host cells for a long time. |
| Keywords: | picomaviruses apoptosis persistent infection |
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