Catalytic asymmetric synthesis of 19,20-dihydroakuammicine |
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Authors: | Ohori K Shimizu S Ohshima T Shibasaki M |
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Institution: | Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan. |
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Abstract: | An enantiocontrolled total synthesis of 19,20-dihydroakuammicine using a catalytic asymmetric Michael addition of dimethyl malonate to cyclohexenone as the key step is described. The above catalytic asymmetric Michael addition proceeds quite efficiently in the presence of a heterobimetalic asymmetric catalyst (ALB-KO-t-Bu-MS 4A, 0.3 mol%), giving the corresponding Michael adduct in 94% yield and 99% ee. |
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