Microdomain-forming proteins of different families in common signal pathways |
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Authors: | K A Arkhipova I B Zborovskaya |
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Institution: | 1. Institute of Carcinogenesis, Blokhin Russian Cancer Research Center, Kashirskoye sh., 24, Moscow, 115478, Russia
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Abstract: | Lipid rafts are the lateral assemblies of cholesterol, sphingomyelin, glycosphingolipids, and specific proteins within the cell plasma membrane. These microdomains are involved in a number of important cellular processes including membrane rearrangement, protein internalization, signal transduction, and the entry of viruses into a cell. Some of the lipid rafts are stabilized by special microdomain-forming proteins such as caveolins, SPFH domain-containing superfamily, tetraspanins, galectins, which maintain the integrity of rafts and regulate many resident proteins, thereby participating in nearly all life processes of cells. However, such classes of microdomain-forming proteins are still considered separately from each other. In this review we have tried to perform a complex analysis of microdomain-forming proteins in cell regulation by the example of EGFR receptors, integrins, and matrix metalloproteinases. |
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