Pathogenicity of the Y form as compared to M form in experimentally inducedCandida albicans infections

Experimental pathogenicity of the Y form and the M form ofC. albicans separated with a high degree of purity has been evaluated. Experiments are described in which the two morphological forms ofC. albicans were separately inoculated intradermally, intraperitoneally and intravenously in mice and rabbits. In suitable conditions, higher pathogenicity was significantly provoked by the Y form ofC. albicans.

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Riassunto E' stato effettuato uno studio sperimentale sulla patogenicità esercitata nei topini e nei conigli dalle forme morfologiche Y e M dellaC. albicans, separate tra di loro con un alto grado di purezza. Le due forme Y e M sono state inoculate, separatamente, nei conigli per via endovenosa oppure intradermica, nei topini per via intraperitoneale.Nelle condizioni sperimentali seguite, laC. albicans presenta una piú alta patogenicità della forma Y rispetto la forma M.