| 工业分枝杆菌植物甾醇转化途径及菌种改造研究进展 |
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| 引用本文： | 李欣,成细瑶,彭飞,陈甜,黄永棋,苏正定. 工业分枝杆菌植物甾醇转化途径及菌种改造研究进展[J]. 工业微生物, 2021, 51(1): 50-56 |
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| 作者姓名： | 李欣 成细瑶 彭飞 陈甜 黄永棋 苏正定 |
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| 作者单位： | 工业发酵教育部重点实验室和湖北省工业微生物重点实验室;湖北工业大学生物工程与食品学院,武汉430068 |
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| 摘 要： | 相比于传统的化学转化法,微生物转化法在甾体药物的生产中显示出了明显的优势.利用分枝杆菌降解植物甾醇可以生成一系列甾体药物的中间体,这极大地方便了甾体药物的生产.通过基因工程、分子生物学和结构生物学等学科的技术手段,人们对甾醇转化菌株进行了深入的探索和改造.本文对工业分枝杆菌植物甾醇转化途径及菌种改造的研究进展进行了综述...
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| 关 键 词： | 分枝杆菌 甾醇代谢途径 基因改造 |
Research progress on transformation pathway and strain modification of phytosterols from Mycobacterium |
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| LI Xin,CHENG Xiyao,PENG Fei,CHEN Tian,HUANG Yongqi,SU Zhengding. Research progress on transformation pathway and strain modification of phytosterols from Mycobacterium[J]. Industrial Microbiology, 2021, 51(1): 50-56 |
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| Authors: | LI Xin CHENG Xiyao PENG Fei CHEN Tian HUANG Yongqi SU Zhengding |
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| Affiliation: | (Key Laboratory of Industrial Fermentation(Ministry of Education)and Key Laboratory of Industrial Microbiology of Hubei Province,Department of Biological and Food Engineering,Hubei University of Technology,Wuhan 430068) |
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| Abstract: | Compared with the traditional chemical transformation method,the microbial transformation method shows obvious advantages in the production of steroidal drugs.The use of Mycobacteria to degrade phytosterols can generate a series of steroidal drug intermediates,which greatly facilitates the production of steroidal drugs.Through the technical means of genetic engineering,molecular biology and structural biology,people have conducted in-depth exploration and transformation of sterol-transforming strains.In this article,the research progress on the transformation pathway of plant sterols of industrial Mycobacterium and the transformation of strains was reviewed. |
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| Keywords: | Mycobacterium sterol metabolism pathway genetic modification |
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