首页 | 本学科首页   官方微博 | 高级检索  
     


Peptide analogues of angiotensinogen. Effect of peptide chain length on renin inhibition
Authors:J J Plattner  J Greer  A K Fung  H Stein  H D Kleinert  H L Sham  J R Smital  T J Perun
Affiliation:1. Soil, Water, and Environmental Science Department, University of Arizona, Tucson, AZ, 85721, United States;2. Hydrology and Atmospheric Sciences Department, University of Arizona, Tucson, AZ, 85721, United States;3. Institute of Water Resources and Environment, Jilin University, Changchun, 130026, PR China;4. Department of Plant & Environmental Sciences, New Mexico State University, Las Cruces, NM, United States;1. National University of Science and Technology "MISIS", Leninskiy prospect 4, Moscow 119049, Russian Federation;2. Institute of Organic Chemistry RAS, Leninskiy prospect 47, Moscow 119991, Russian Federation;3. Emanuel Institute of Biochemical Physics RAS, Kosygina 4, Moscow 119334, Russian Federation;4. Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, bld. 1, Moscow 121205, Russian Federation;5. Moscow State University, GSP-1, Leninskie Gory, Moscow 119991, Russian Federation;6. Centre for Materials Science and School of Chemistry and Physics, Queensland University of Technology (QLD), 2 George str., Brisbane, QLD 4000, Australia;7. World Premier International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), Namiki 1–1, Tsukuba, Ibaraki 3050044, Japan;8. Plekhanov Russian University of Economics, 36 Stremyanny per., Moscow 117997, Russian Federation;1. Key Laboratory of Eco-Environments in Three Gorges Reservoir Region (Ministry of Education), School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, People’s Republic of China;2. Chongqing Academy of Metrology and Quality Inspection, Chongqing 400715, People’s Republic of China;1. Geography and Urban Regional Analysis, University of North Carolina at Charlotte, 9201 University City Blvd, Charlotte, NC 28223, USA;2. Department of Geography & Earth Sciences, University of North Carolina at Charlotte, 9201 University City Blvd, Charlotte, NC, 28223, USA
Abstract:Renin inhibition was evaluated for a series of peptide analogues of angiotensinogen with different chain lengths. Systematic deletion of amino acid residues from the hexapeptide BocPheHisLeuR-ValIleHisOCH3 showed that the presence of residues at the N-terminal Phe and His positions was essential for efficient enzyme-inhibitor binding whereas the C-terminal Ile and His residues were much less important. Synthesis of a tetrapeptide analogue shortened at the C-terminus and containing modified side chains produced a potent inhibitor of renin which demonstrated hypotensive activity in a salt depleted monkey.
Keywords:
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号