VLDL apoprotein secretion and apo-B mRNA level in primary culture of cholesterol-loaded rabbit hepatocytes |
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| Authors: | V A Kosykh A P Surguchov E A Podres D K Novikov A B Sudarickov Repin" target="_blank">V S Berestetskaya YuVRepin V N Smirnov |
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| Institution: | USSR Cardiology Research Center, Academy of Medical Sciences, Moscow. |
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| Abstract: | Incubation of cultured rabbit hepatocytes with beta very low density lipoproteins (beta-VLDL) induces a dose-dependent increase in cell cholesterol (CH) content and VLDL apoprotein (apo) B and E secretion without change in apo-B mRNA level. These data suggest that beta-VLDL may exert a stimulatory effect on hepatic apo-B production at the co-translational and/or posttranslational level. |
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